TransForm Pharmaceuticals - Shaping the Medicines of Tomorrow

Both the solid form of an active pharmaceutical ingredient (API) as well as its formulation with other excipients can have a very significant impact on product performance, including its stability, rate of onset and bioavailability. TransForm optimizes product performance by integrating deep scientific knowledge with our proprietary best-in-class high-throughput form and formulation experimentation technologies and state-of-the-art informatics.

We use these capabilities to identify new and build more value into the J&J pipeline of products by maximizing the clinical and commercial value of drug candidates and marketed products.

One example of how different solid forms of the same substance can have very different properties is the element carbon. One form of carbon is graphite. Another form of carbon is diamond. Created under very different conditions, the two forms represent unique crystalline molecular arrangements of the same substance. Likewise, drug substances can have many crystalline forms, and their value depends heavily on choosing the best one for development or for a particular delivery system, and then formulating it with the best excipients.

Graphite		Diamond		Ring
	Form	Formulation

Impact
Small Molecule Drugs:			Biologics/Vaccines:
Solubility			Stability
Dissolution Rate			Solubility
Stability			Activity, yield
Bioavailability			Efficacy

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